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In a cross between a male and female, both heterozygous for sickle cell anaemia gene, what percentage of the progeny will be disease

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In a cross between a male and female, both heterozygous for sickle cell anaemia gene, what percentage of the progeny will be diseased?

(1) 100% (2) 50% (3) 75% (4) 25%

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4) 25% is correct option

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